Oncology

generic:
doxorubicin

classification:
antitumour antibiotic

composition: .
each vial contains:
doxorubicin hydrochloride…10mg
lactose ……q. S.

mechanism of action:
doxorubicin damages dna by intercalation of the anthracycline portion, metal ion chelation, or by generation of free radicals. Doxorubicin has also been shown to inhibit dna topoisomerase ii that is critical to dna function. Cytotoxic activity is cell cycle phase-nonspecific.

indication:

• acute lymphoblastic leukemia
• acute myeloblastis leukemia
• acute non-lymphoblastic leukemia
• breast cancer
• hodgkin's lymphoma
• small cell lung cancer
• non-hodgkin's lymphoma
• ovarian cancer
• ewing's sarcoma

strengths:

GENERIC:
CYTARABINE, CYTOSINE ARABINOSIDE (Ara-C)

CLASSIFICATION:
Antimetabolite

COMPOSITION:
Each ml contains Cytrabine ………….100mg.

MECHANISM OF ACTION:
Its mode of action is due to its rapid conversion into cytosine arabinoside triphosphosphate, which damages DNA when the cell cycle holds in the S phase (synthesis of DNA). Rapidly dividing cells, which require DNA replication for mitosis, are therefore most affected. Cytosine arabinoside also inhibits both DNA and RNA polymerases and nucleotide reductase enzyme needed for the DNA synthesis. Cytarabine is rapidly deaminated in the body into the inactive uracil derivative form and therefore, it is often given by continuous intravenous infusion.

INDICATION:

• Acute myelogenous leukemia
• Meningeal leukemia
• Chronic myelogenous leukemia
• Erythroleukemia
• Non-Hodgkin's lymphoma.

STORAGE:

• Store below 25°C

GENERIC:
CYTARABINE, CYTOSINE ARABINOSIDE (Ara-C)

CLASSIFICATION:
Antimetabolite

COMPOSITION:
Each ml contains Cytrabine ………….100mg.

MECHANISM OF ACTION:
Its mode of action is due to its rapid conversion into cytosine arabinoside triphosphosphate, which damages DNA when the cell cycle holds in the S phase (synthesis of DNA). Rapidly dividing cells, which require DNA replication for mitosis, are therefore most affected. Cytosine arabinoside also inhibits both DNA and RNA polymerases and nucleotide reductase enzyme needed for the DNA synthesis. Cytarabine is rapidly deaminated in the body into the inactive uracil derivative form and therefore, it is often given by continuous intravenous infusion.

INDICATION:

• Acute myelogenous leukemia
• Meningeal leukemia
• Chronic myelogenous leukemia
• Erythroleukemia
• Non-Hodgkin's lymphoma.

STORAGE:

• Store below 25°C

GENERIC:
EPIRUBICIN

CLASSIFICATION:
Antitumour antibiotic

MECHANISM OF ACTION:
It intercalates into DNA, which results in inhibition of DNA synthesis and function. It inhibits Topoisomerase II by forming a cleavable complex with Topoisomerase II and DNA. It is also involved in oxidation/reduction reactions by generating cytotoxic oxygen free radicals, which can cause single & double-stranded DNA breaks.

COMPOSITION:
Each vial contains:Epicin 10mg
Epirubicin Hydrochloride B.P.……..10mg
Methyl Paraben I.P…..2mg
Lactose I.P. ……..q.s.
Each vial contains: Epicin 50mg
Epirubicin Hydrochloride B.P.……..50mg
Methyl Paraben I.P…..20mg
Lactose I.P. ……..q.s.

INDICATIONS:
Epirubicin is recommended for the treatment of metastatic breast cancer. Epirubicin may also be used as a component in the adjuvant treatment of early stage breast cancer for pre- and peri- menopausal women.