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Home » Our Products » Therapeutic Segmentation » Oncology
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Oncology

We supply variety of methotrexate tablets, busulfan tablets, l- asparaginase injection, cytotoxic tablets, dacarbazine injection, 6-mercaptopurine tablets, oxaliplatin injection etc.

Hitrex

Hitrex Generic:
methotrexate

classification:
antimetabolite

mechanism of action:
cell cycle-specific antifolate analog, active in s-phase of the cell cycle. Enters cells through specific transport systems mediated by the reduced folate carrier and the folate receptor protein. Inhibition of dihydrofolate reductase (dhfr) resulting in depletion of critical reduced folates. Inhibition of de novo thymidylate synthesis.

composition
hitrex injection - 15mg/3ml
each ml contains methotrexate u. S. P. . . . . . . . . . . . . . . . . . . . . . . . 5mg
water for injection u. S. P. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Q. S.
hitrex 50mg/2ml
each ml contains methotrexate u. S. P. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25mg
water for injection u. S. P. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . …………. . . . . . . . . . . . . . . Q. S.
hitrex 500mg/5ml
each ml contains methotrexate u. S. P. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100mg
water for injection u. S. P. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Q. S.

indication:
breast cancer.
head and neck cancer.
osteogenic sarcoma.
acute lymphoblastic leukemia.
non-hodgkin's lymphoma.
meningeal leukemia
bladder cancer.
colorectal cancer

storage:
store vials between 36° and 77°f in original package to protect from bright light.

strengths:
2. 5 mg tab, 15 mg inj. & 50mg inj.

LEUCOGINASE

LEUCOGINASE GENERIC:
L- ASPARAGINASE
MECHANISM OF ACTION:
Asparaginase hydrolyzes the amino acid L-asparagine to L-aspartic acid and ammonia. Asparagine is required for DNA synthesis and cell survival; however, most cells are capable of synthesizing asparagine from glutamine. Acute lymphoblastic leukemia (ALL) cells lack adequate levels of the required enzyme, asparagine synthetase, and cannot survive asparagine depletion. Asparaginase is cycle-specific for the G1 phase.

COMPOSITION:
Each Vial Contains
L-asparginase ……5000 I.U.
Glycine……….q.s.

Each vial contains]
L-asparginase ……10000 I.U.
Glycine……….q.s.

INDICATION:
  • Acute lymphoblastic leukemia
  • Chronic lymphocytic leukemia
  • Hodgkin's lymphoma
  • Non-Hodgkin's lymphoma

STRENGTHS:
  • 5000 I.U
  • 10000 I.U

STORAGE:
  • Store between 2º to 8ºC. Do not freeze

Oncodac

Oncodac Generic:
dacarbazine

classification:
alkylating agent

composition:
oncodac 100mg
each vial contains dacrbazine usp………100mg
citric acid i. P. ……. . Q. S.
mannitol i. P. Q. S.

oncodac 200 mg
each vial contains dacrbazine usp………200mg
citric acid i. P. ……. . Q. S.
mannitol i. P. Q. S.

oncodac 500 mg
each vial contains dacrbazine usp………500mg
citric acid i. P. ……. . Q. S.
mannitol i. P. Q. S.

mechanism of action:
dacarbazine is a structural analogue of imidazole carboxamide, a purine precursor. Dacarbazine undergoes activation via cytochrome p450 in the liver to the reactive compound, methyltriazenoimidazole carboxamide (mtic). The cytotoxicity of mtic is thought to be due primarily to the formation of methylcarbonium ions that attack nucleophilic groups in dna. Dacarbazine may also inhibit dna and rna synthesis by acting as a purine analogue and by interacting with sulfhydryl groups. Dacarbazine is cell cycle phase-nonspecific and is mildly immuno-suppressive

indications:
  • hodgkin's lymphoma
  • malignant melanoma

storage:
  • store in a refrigerator 2°c to 8°c (36°f to 46°f). Use within 8 hours of reconstitution. Protect from light.

strengths:
  • oncodac inj 100 mg
  • oncodac inj 200 mg
  • oncodac inj 500 mg

Xplatin

Xplatin Generic:
oxaliplatin

classification:
platinum analog
  • mechanism of action: third-generation platinum compound.
  • cell cycle-nonspecific with activity in all phases of the cell cycle.
  • covalently binds to dna with preferential binding to the n-7 position of guanine and adenine.
  • reacts with two different sites on dna to produce cross-links, either intrastrand (>90%) or interstrand (<5%). Formation of dna adducts results in inhibition of dna synthesis and function as well as inhibition of transcription.
  • dna mismatch repair enzymes are unable to recognize oxaliplatin-dna adducts in contrast with other platinum-dna adducts as a result of their bulkier size.
  • binding to nuclear and cytoplasmic proteins may result in additional cytotoxic effects.

composition:
xplatin 50mg/100mg
oxaliplatin……. . 2mg
water for injection i. P. ……. Q. S.

indications:
  1. metastatic colorectal cancer-fda approved as second-line therapy in combination with 5-fu/lv (folfox4) in patients whose disease has recurred or progressed during or within six months of completion of first-line therapy with the combination of bolus 5-fu/lv and irinotecan
  2. metastatic colorectal cancer-fda-approved as first-line therapy in combination with 5-fu/lv (folfox4).
  3. early-stage colon cancer-fda-approved as adjuvant therapy in combination with 5-fu/lv (folfox4) in patients with stage iii colon cancer and in those with high-risk stage ii disease.
  4. pancreatic cancer.
  5. gastric cancer

storage:
store under normal lighting conditions at 25°c (77°f); excursions permitted to 15-30°c (59-86°f) [see usp controlled roomtemperature].

strengths:
50mg/25ml, 100mg/50ml

Calcivorin

Calcivorin generic:
leucovorin calcium

classification:
miscellaneous

composition:
each ml contains
leucovorin calcium eqivalenr to leucovorin. . 7. 5mg
water for injection i. P. ………. . Q. S.

each ml contains
leucovorin calcium eqivalenr to leucovorin…. Mg
water for injection i. P. ………. . Q. S.

each uncoated tablets contains:
leucovorin calcium ………. 15 mg

mechanism of action:
leucovorin is an active metabolite of folic acid and an essential coenzyme for nucleic acid synthesis. Leucovorin can be used to selectively "rescue" cells from the adverse effects of methotrexate or to increase the efficacy of fluorouracil.

indications:
  • leucovorin rescue after methotrexate in osteosarcoma
  • enhance cytotoxicity of fluorouracil in colorectal cancer.



storage:
  • store in refrigerated conditions (2 to 8°c)
  • protect from direct light and heat.


strengths:
  • calcivorin inj 50mg/5 ml
  • calcivorin inj 15 mg/2 ml
  • calcivorin tab. 15mg

Thiog 40mg 10 X 10 Tablets

Thiog 40mg 10 X 10 Tablets Generic Name : Tab.Thioguanine

Indication :
Acute Myelogenous Leukemia,Acute Lymphocytic Leukemia,Chronic Lymphocytic Leukemia

Our Brand Name :
THIOG

Puricor 50mg 10 X 10 Tablets

Generic Name : Tab.Mercaptopurine

Indication :
Acute Lymphocytic Leukemia,Acute Myelogenous Leukemia

Our Brand Name :
PURICOR

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